Which Natural Topical DHT Blocker Product Is Best?

This review compares seven topical DHT blocker products which all contain natural substances (including saw palmetto) and identifies the problems some of these creams, serums and lotions have.

The table below can help you decide which, if any, of these products is the best one to use. DHT (dihydrotestosterone) is, of course, the hormone with the biggest connection to hair loss (androgenetic alopecia).

Clearly then, it's the hormone that most men (and many women) try to counteract by using products containing natural DHT blocker substances (like saw palmetto) as alternatives to the drug Propecia.*

* Propecia also blocks DHT production but can cause nasty side effects as well.

So, if you're thinking about trying an all-natural approach to stop your hair loss, use the table below to quickly compare seven of the most popular topical DHT blocker products. Then read the important notes underneath the table.

Essential fatty acid gel supplement

Also use the following codes to identify the different fatty acids in the table.

ALA = Alpha Linolenic acid (omega 3)
GLA = Gamma linolenic acid (omega 6)
LA = Linoleic acid (omega 6)

Topical DHT blocker product chart

Important Notes

There are literally dozens of topical DHT blocker products that contain saw palmetto. Those included in the table have been selected partly because they're some of the most popular, but also to highlight three important points:

1. Scientific studies

You can see that scientific studies have been done for four of the seven products. Here’s how these studies were performed:

Nisim conducted trials on 148 men and assessed performance using photos and a hair count.

Procerin conducted trials on 32 men and assessed performance using physical examination, photos and a questionnaire.

Revivogen conducted trials on 34 men and five women, and assessed performance using before and after questionnaires.

HairGenesis had some of its ingredients tested in a lab.

2. Saw palmetto safety

From the chart, you can see that only Procerin states that its topical DHT blocker product is intended to be used by men only. All the rest suggest that there’s no problem for women to use them as well.

But, on page 2, the potential side effects of trying to use saw palmetto for hair loss were explained, including the risk to pregnant women. Still, whether or not such problems in women could be caused by applying DHT inhibitors just to the scalp is uncertain.

Saw palmetto palm tree

3. Other topical DHT blocker ingredients

Saw palmetto is a DHT blocker plant

All products reviewed on this page contain saw palmetto as a standardized extract (which is the most effective form). But, there are several other DHT blocker substances within these products as well.

From the final column in the table, you can see that Crinagen and Revivogen seem to have virtually identical active ingredients (although, interestingly, both official websites state that their particular formulation is unique).

When I looked more closely at these two products ingredient lists, it appears that they differ slightly due to another ingredient, beta-sitosterol. 

Beta-sitosterol is a biologically active substance that occurs naturally within saw palmetto in small amounts. However, Crinagen doesn’t list beta-sitosterol as an ingredient at all (i.e., even though it does contain saw palmetto), and Revivogen lists beta-sitosterol separately from saw palmetto.

So, make of all that what you will!

Procerin also contains very similar active ingredients to Revivogen and Crinagen. But, to what extent depends on what website you're visiting - the UK website does not list seven ingredients that are listed on the US website (including GLA and zinc).

Shen Min has a massive 39 ingredients, but it looks like saw palmetto and nettle are the only two DHT blocker substances it contains. And in HairGenesis and Nisim, saw palmetto seems to be the only one.

All of which begs the question…

Do you need to use more than just saw palmetto?

Well, obviously most manufacturers think so!

And I think there are two reasons for this:


1. Saw palmetto is hardly unique. There are loads of hair regrowth products that contain this herb. So, to try and stand out from the crowd, manufacturers often add many more active ingredients, including hair growth stimulators and extra DHT inhibitors. Even so, some products still seem virtually identical (as is the case with Crinagen and Revivogen).

2. DHT inhibitors work by either blocking 5-alpha reductase from forming DHT, blocking DHT from attaching to androgen receptors, or both. Saw palmetto might do both. But, that’s not known for sure. So, adding other substances that can affect DHT production, might guarantee that the DHT levels in your hair follicles will decrease as intended.


Gamma linolenic acid (GLA) is said to be the most potent natural DHT blocker. So, including this particular ingredient does seem to make sense. But, as for adding a whole multitude of DHT blockers, frankly I don’t see the point.

Product Names, Form and How to Use Them

If you are still interested in any of these topical DHT blocker products, here's a quick run-down of all the different forms they take, and the best way to apply them. The full product names have also been given:

Crinagen - Although they have just a single product, one page of the website describes it as a topical lotion, and another as a topical spray. How to use: not stated.

Folligen Cream and Folligen Lotion products - Identical ingredients but in different proportions (the cream is thicker). How to use: leave on scalp for six or more hours. You can also use their Emu Oil for Hair product to help with absorption. Learn more about Folligen products?

HairGenesis Trichoceutical Activator Serum Generation VI Maximum Strength Formula(!) - How to use: massage serum into wet hair, leave for just one or two minutes, then rinse out.

Nisim Biofactors Extract - There's an original formula (for oily hair) and gel formula (for dry hair). How to use: apply twice a day - you must also use Nisim NewHair Biofactors Shampoo.

Procerin XT Topical Activator Foam - How to use: you apply the foam one or more times per day depending upon the sensitivity of your skin. The website also states that, for better results, you should use their other product, Procerin Tablets, too.

Revivogen Scalp Therapy - How to use: it's a topical solution you put on every night and then use their other products, Bio-Cleansing Shampoo and Thickening Conditioner every morning.

Shen Min Topical - How to use: Apply up to 20 drops to the scalp every night.

Summary – Using Saw Palmetto and Other DHT Blocker Products

You can see from the last two pages just how complicated and confusing hair loss product research can be!

And, if you've read all four pages in this section, you'll know that, whilst using saw palmetto for hair loss is generally considered to be a safe natural alternative to finasteride (Propecia), using this herb is not without its issues.

These included:

  • The exact mechanism in which saw palmetto may benefit hair follicles is not fully understood, which raises uncertainty as to whether or not saw palmetto hair loss products can provide any real help.

  • There are potential side effects from saw palmetto and other DHT blocker agents for both men and women. Basically, hormone regulation is very much a balancing act – too much interference and undesirable side effects can develop.

All this uncertainty surrounding these powerful DHT blocker products strongly suggests to me that, by taking them, you might be risking both your hair and your health.

Furthermore, DHT blocker substances don’t address the underlying mechanism that causes this type of hair loss in the first place - skull expansion.

So, personally, I don’t think using saw palmetto products for hair regrowth is such a good idea.

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